Speakers & provisional titles

Mitochondria, Protein homeostasis and Cell Death

• Richard KitsisCross-Talk between Ferroptosis and Necroptosis
• Sonia SinghTargeting the JAK1-STAT3 pathway to treat cardiac proteinopathy
• Asa GustafsonExtracellular Vesicles and Cellular Quality Control Mechanisms in Cardioprotection
• Luca ScorranoMitochondrial Shape, Autophagy, and Heart Failure: a Triad to Combat.
• Petra KienesbergerRole of lipid phosphate phosphatases in cardiac energy metabolism and function

Health and Disease Mechanisms of Women’s Heart

• Inna Rabinovich-NikitinThe cardiac pathophysiological outcomes of shift work during pregnancy
• Ines Falcão-PiresSex differences in (reverse) remodeling of the heart
• Maggie LamCardiac sex-age interactions and proteogenomic insights
• Rudolf de BoerHeart failure with preserved ejection fraction in humans and mice: what does sex have to do with it?
• Raffaele CoppiniSex differences in cardiac electrophysiology and drug response

New mechanisms to protect against heart failure with preserved ejection fraction

• Johannes BacksTargeting Class IIa HDAC signaling in cardiometabolic disease
• Rebecca RitchieCyclic GMP as a therapeutic target for HFpEF
• Taketaro SadahiroTrans-differentiation of cardiac fibroblasts reveals a new molecular mechanisms for HfpEF
• Brandon BiesiadeckiTyrosine kinase phosphorylation of troponin I is a novel mechanism to increase myocardial relaxation
• Judy de HaanUnique immunometabolic treatment strategies to protect against HFpEF

New players in mitochondrial calcium regulation

• Livia HoolCommunication between LTCC and the mitochondria
• Diego De StefaniTMEM65 controls mitochondrial Ca2+ extrusion
• Nina KaludercicTargeting mitochondrial ROS formation in cardiac pathology
• Melanie PaillardSarcoplasmic reticulum-mitochondria communication in diabetic HFpEF
• Toshiyuki YanoA new facet of myocardial necroptosis: crosstalk with mitochondrial dynamics and autophagy

Mechanisms of cardiac dysfunction in diabetic heart disease

• Jonathan KirkCardiomyocyte myofilament glycation in diabetes
• Junichi SadoshimaMitophagy & the diabetic heart
• Kim MellorGlycophagy and glycogen in diabetic cardiomyopathy
• Melanie WhiteMulti-omics approaches to investigating diabetic cardiomyopathy
• Lisa HeatherCardiac metabolic remodeling in diabetes

Interorgan communications in heart failure

• Yukiteru NakayamaMulti-organ cross-talk in heart failure
• Gabriele SchiattarellaLiver/adipose tissue-Heart cross talk in HFpEF and Cardiometabolic disease
• Stefanie DimmelerHematopoietic mutations and cardiac fibrosis
• Daniela CarnevaleBrain-heart cross talk in HF
• TBD

Shaping the cardiac proteome in health and disease

• Yibin WangRegulation of the cardiac translatome
• Sakthivel SadayappanMyosin S2 and cMyBP-C Interactions in Cardiac Function and Hypertrophic Cardiomyopathy
• Shirin DoroudgarThe unfolded protein response and ER stress
• Federica AccorneroRNA binding proteins in stress responsive gene regulation
• Diederik KusterProteostasis in hypertrophic cardiomyopathy

Modulators of cell-cell communication in heart failure

• Thomas ThumOrgan cross-talk during heart failure
• Julie McMullenImpact of heart-derived factors from the protected and failing heart
• Jose Angel Nicolas AvilaMacrophages as protectors of mitochondrial quality in the heart and beyond
• Kristin StanfordExercise-induced interorgan communication
• Ichiro ManabeInnate immune memory and organ cross-talk in heart failure

E-C Coupling: channels, regulators and key players

• Steven MarxRad regulation of cardiac calcium channels and cardiac contractility
• Long-Sheng SongJunctophilin-2 Regulation of Cardiac E-C Coupling and Transcription
• Shi-Qiang WangGRK2 regulation of beta-adrenergic signaling and Ca2+ handling in the heart
• Jeffrey EriksonS-Nitrosylation of CaMKII and cardiac arrhythmia
• Shanna HamiltonMechanisms of mitochondrial morphology changes in RyR2 mutation-associated CPVT

Regulatory mechanisms of intracellular Ca2+ signalling and excitability via intracellular organelle cross-talk

• Bjorn C. KnollmannRyR2 as an antiarrhythmic drug target
• Mario DelmarArrhythmogenic Remodeling of Intracellular Calcium Dynamics in ARVC
• Deli ZhangCritical role of mitochondrial remodeling in cardiac arrhythmia
• Ayako TakeuchiImpact of Ca2+ crosstalk between mitochondria and sarcoplasmic reticulum in cardiomyocyte during workload transition
• Hideaki InazumiCritical role of NRSF-GNAO1 pathway in regulating Ca2+ signaling in ventricular myocytes

Cardiac Ca2+ handling as a therapeutic target

• Eduardo BerteroMitochondrial calcium signaling and redox homeostasis in cardiac health and disease.
• Stephan LehnartCa2+-binding ferlin protein expression improves left-ventricular function post-myocardial infarction
• William (Bill) LouchDevelopmental and Sex-dependent particularities of cardiac Ca2+ handling and its therapeutic relevance
• Niels VoigtImpaired intracellular buffering as arrhythmogenic substrate in cardiomyocytes from patients with Afib
• Luis GonanoModulation of Sarcoplasmic Reticulum Ca2+ release and uptake: focus on the Ca2+ waves and Ca2+ alternans relationship

Non-Myocyte Contributors to Arrhythmia

• Jim BellCardiac adiposity and arrhythmias
• Arjun DebFibroblasts regulate cardiac excitability and arrhythmogenesis
• Molly O'ReillyExploring the role of neuronal dysfunction in inherited arrhythmia syndromes
• Patrizia CamellitiFibroblast-Myocyte interactions and their impact on cardiac electrophysiology
• Sebastian ClaussMacrophages and Electrical conduction in the Heart

Cardiac Hippo-YAP signaling

• Enzo PorrelloRole of Hippo-YAP in cardiac development and regeneration
• James MartinTargeting Hippo-YAP signaling in heart failure
• Mei XinBeta adrenergic and YAP crosstalk regulate cardiomyocyte proliferation
• Dominic Del ReThe role of YAP in cardiac fibrosis
• Ichiro ShiojimaWnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytes

Drug targets in Heart Failure

• Simon LebekTargeting CAMKII to mend the failing heart
• Tim McKinseyHDACs as target for therapy in heart failure
• Lilei ZhangTreating heart failure with novel REV-ERB agonist
• Priscila SatoGRK2 and Cardio-metabolic signaling in Heart Failure
• Atsushi HoshinoDevelopment of genome editing tools based on deep mutational scanning

Mediators of protein phosphorylation in cardiac disease

• Maria KontaridisRole of TRPM4 in Cardiac Disease and Arrhythmogenesis
• Xander WehrensPP1 isoform-specific regulation of cardiac arrhythmias
• Alessandra GhigoBeta-adrenergic regulation of cardiac function through PI3K signaling
• Kate WeeksThe cardiac phosphatome in metabolic heart disease & failure
• Nicole PurcellPHLPPs in cardiac physiology & pathophysiology

Cutting-edge research on genomics and omics

• Gianluigi CondorelliNon-coding RNAs as epigenetic markers of myocardial diseases
• Roger FooGenome and omics analyses in CVDs
• Seitaro NomuraSingle-cell and spatial omics analysis to develop cardiovascular precision medicine
• Eddy KizanaCardiotropic AAV variants
• Miguel TorresPluripotency, Competition and Heart Regeneration

Epigenetic Regulation of Cardiac Stress

• Thomas VondriskaHistone variants as mechanical stress sensors
• Liming PeiEpigenetic insights into cardiac biology and disease
• Li QianEpigenetic regulation of direct cardiac reprogramming
• Jan LamerdingNew insights into the pathogenic mechanism of cardiac laminopathies and the therapeutic effect of LINC complex disruption
• Sam El-OstaEpigenetics in cardiovascular health and disease

Spatial organization of protein synthesis in the myocardium

• Marie-Jo MoutinThe tubulin code as spatial regulator - what can we learn from the brain?
• Izhak KehatLocalized protein translation in the heart
• Benjamin L. ProsserMicrotubule-mediated spatial control: directing translation and remodeling in the myocardium
• Gail A. RobertsonCoordinated cotranslational association of ion channels mRNA in the heart
• Julia GorelikBeta 1 and beta 2 receptor translation dynamics in healthy and failing heart

Current status of cardiac regeneration therapy: from preclinical study to clinical trial

• Keiichi FukudaCurrent status of human iPS cell derived cardiomyocyte transplantation to the patients with severe heart failure due to ischemic heart disease in LAPiS study
• Wolfram-H ZimmermanniPS-cell derived engineered heart muscle in patients with advanced heart failure
• Wataru KimuraNucleotide and lipid dynamics in postnatal regeneration and stress response
• Charles MurryCan Academics Make a Stem Cell Drug?
• Monika GladkaHarnessing gene therapies to enhance vessel formation and cardiac repair

Regulation of endogenous cardiac regeneration

• Mauro GiaccaRNA therapies for cardiac regeneration
• Eldad TzahorAdvancing Cardiac Therapeutics
• Eva van RooijCreating a repair permissive heart
• Diana NascimentoA switch in cardiac fibroblasts hinders regeneration after neonatal myocardial infarction
• Caitlin C. O'MearaModulating cell polarity and cytoarchitecture to promote cardiomyocyte regeneration

Metabolic reprogramming to prevent and treat heart failure

• Zoltan AranyUnderstanding Human Cardiac Metabolism
• Tao LiBCAA metabolism and HFpEF
• Cat MakerewichModulating Cardiac Mitochondria with Micropeptides
• Aijun SunMitochondrial Transfer: a Therapy for Cardiomyopathy?
• Daniel KellyTargeting Metabolic Maturation in the Developing and Diseased Heart

Mechanistic insights of the role of impaired cardiac metabolism in driving heart failure

• Christoph MaackMechano-energetic uncoupling in HFrEF and HFpEF
• Veronica EisnerMitochondrial crystae dynamics in the aging heart
• Alexander PintoNew mechanistic insights into cardiac fibrosis and heart failure in diabetes emerging from cutting-edge computational biology and single-cell omics
• Valentina ParraIdentification of new transcription factors involved in the control of cardiac hypertrophy and mitochondrial metabolism of cardiomyocytes
• TBD

Sex matters in Cardiovascular remodeling

• Manuel MayrProteomic Atlas of Atherosclerosis
• Julia RitterhoffMetabolic therapies for heart failure
• John UssherSex differences in diabetic-related cardiovascular disease: insights from basic science
• Yang CaoGenetic dissection of mitochondrial dysfunction in heart failure
• TBD

Targeting metabolism to prevent heart failure progression: HFrEF vs HfpEF

• Jenny van EykMyocardial proteome defines the continuum in human HFpEF
• Rong TianMitochondria in HFpEF
• Luc BertrandTargeting glucose-derived O-GlcNAcylation pathway in heart failure
• Mahmoud AbdellatifTargeting nicotinamide adenine dinucleotide for the treatment of HFpEF
• Ming XuThe protective role of exercise on children metabolic syndrome