Symposium

Cardiac Ca2+ handling as a therapeutic target

Chair

Cecilia Mundina, Davor Pavlovich

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  Mitochondrial calcium signaling and redox homeostasis in cardiac health and disease.

  Eduardo Bertero
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  Modulation of Sarcoplasmic Reticulum Ca2+ release and uptake: focus on the Ca2+ waves and Ca2+ alternans relationship

  Luis Gonano
• 
  Ca2+-binding ferlin protein expression improves left-ventricular function post-myocardial infarction

  Stephan Lehnart
• 
  Developmental and Sex-dependent particularities of cardiac Ca2+ handling and its therapeutic relevance

  William (Bill) Louch
• 
  Impaired intracellular buffering as arrhythmogenic substrate in cardiomyocytes from patients with Afib

  Niels Voigt

Cardiac Hippo-YAP signaling

Chair

Metin Avkiran, Emilio Hirsch

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  The role of YAP in cardiac fibrosis

  Dominic Del Re
• 
  Targeting Hippo-YAP signaling in heart failure

  James Martin
• 
  Role of Hippo-YAP in cardiac development and regeneration

  Enzo Porrello
• awaiting
  Wnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytes

  Ichiro Shiojima
• 
  Beta adrenergic and YAP crosstalk regulate cardiomyocyte proliferation

  Mei Xin

Current status of cardiac regeneration therapy: from preclinical study to clinical trial

Chair

Kaoru Ito, Jop Van Berlo

• 
  Current status of human iPS cell derived cardiomyocyte transplantation to the patients with severe heart failure due to ischemic heart disease in LAPiS study

  Keiichi Fukuda
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  Harnessing gene therapies to enhance vessel formation and cardiac repair

  Monika Gladka
• 
  Nucleotide and lipid dynamics in postnatal regeneration and stress response

  Wataru Kimura
• awaiting
  Can Academics Make a Stem Cell Drug?

  Charles Murry
• 
  iPS-cell derived engineered heart muscle in patients with advanced heart failure

  Wolfram-H Zimmermann

Cutting-edge research on genomics and omics

Chair

Fadi Charchar, Emily Wong

• 
  Non-coding RNAs as epigenetic markers of myocardial diseases

  Gianluigi Condorelli
• 
  Genome and omics analyses in CVDs

  Roger Foo
• 
  Cardiotropic AAV variants

  Eddy Kizana
• awaiting
  Single-cell and spatial omics analysis to develop cardiovascular precision medicine

  Seitaro Nomura
• awaiting
  Pluripotency, Competition and Heart Regeneration

  Miguel Torres

Drug targets in Heart Failure

Chair

Walter J Koch, Lauren May

• 
  Development of genome editing tools based on deep mutational scanning

  Atsushi Hoshino
• 
  Targeting CAMKII to mend the failing heart

  Simon Lebek
• 
  HDACs as target for therapy in heart failure

  Tim McKinsey
• 
  GRK2 and Cardio-metabolic signaling in Heart Failure

  Priscila Sato
• 
  Treating heart failure with novel REV-ERB agonist

  Lilei Zhang

E-C Coupling: channels, regulators and key players

Chair

Ana-Maria Gomez, Yoshihiko Saito

• 
  S-Nitrosylation of CaMKII and cardiac arrhythmia

  Jeffrey Erikson
• 
  Mechanisms of mitochondrial morphology changes in RyR2 mutation-associated CPVT

  Shanna Hamilton
• 
  Rad regulation of cardiac calcium channels and cardiac contractility

  Steven Marx
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  Junctophilin-2 Regulation of Cardiac E-C Coupling and Transcription

  Long-Sheng Song
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  GRK2 regulation of beta-adrenergic signaling and Ca2+ handling in the heart

  Shi-Qiang Wang

Epigenetic Regulation of Cardiac Stress

Chair

Wei Kong, Koichiro Kuwahara

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  Epigenetics in cardiovascular health and disease

  Sam El-Osta
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  New insights into the pathogenic mechanism of cardiac laminopathies and the therapeutic effect of LINC complex disruption

  Jan Lammerding
• 
  Epigenetic insights into cardiac biology and disease

  Liming Pei
• 
  Epigenetic regulation of direct cardiac reprogramming

  Li Qian
• 
  Histone variants as mechanical stress sensors

  Thomas Vondriska

Health and Disease Mechanisms of Women’s Heart

Chair

Lorrie Kirshenbaum

• 
  Sex differences in cardiac electrophysiology and drug response

  Raffaele Coppini
• 
  Heart failure with preserved ejection fraction in humans and mice: what does sex have to do with it?

  Rudolf de Boer
• 
  Cardiac sex-age interactions and proteogenomic insights

  Maggie Lam
• 
  Ana Filipa Ferreira
• 
  The cardiac pathophysiological outcomes of shift work during pregnancy

  Inna Rabinovich-Nikitin

Interorgan communications in heart failure

Chair

Doan Ngo, KK Talwar

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  Brain-heart cross talk in HF

  Daniela Carnevale
• 
  Hematopoietic mutations and cardiac fibrosis

  Stefanie Dimmeler
• 
  Multi-organ cross-talk in heart failure

  Yukiteru Nakayama
• 
  Liver/adipose tissue-Heart cross talk in HFpEF and Cardiometabolic disease

  Gabriele Schiattarella
• 
  Immune checkpoint signaling and heart failure

  Zoltan Varga

Mechanisms of cardiac dysfunction in diabetic heart disease

Chair

Charles Steenbergen

• 
  Cardiac metabolic remodeling in diabetes

  Lisa Heather
• 
  Cardiomyocyte myofilament glycation in diabetes

  Jonathan Kirk
• 
  Glycophagy and glycogen in diabetic cardiomyopathy

  Kim Mellor
• awaiting
  Mitophagy & the diabetic heart

  Junichi Sadoshima
• 
  Multi-omics approaches to investigating diabetic cardiomyopathy

  Melanie White

Mechanistic insights of the role of impaired cardiac metabolism in driving heart failure

Chair

Yasuchika Takeishi, Junjie Xiao

• 
  Mitochondrial crystae dynamics in the aging heart

  Verónica Eisner
• 
  Mechano-energetic uncoupling in HFrEF and HFpEF

  Christoph Maack
• awaiting
  Identification of new transcription factors involved in the control of cardiac hypertrophy and mitochondrial metabolism of cardiomyocytes

  Valentina Parra
• 
  New mechanistic insights into cardiac fibrosis and heart failure in diabetes emerging from cutting-edge computational biology and single-cell omics

  Alexander Pinto

Mediators of protein phosphorylation in cardiac disease

Chair

Satomi Adachi-Akahane, Zijian Li

• 
  Beta-adrenergic regulation of cardiac function through PI3K signaling

  Alessandra Ghigo
• 
  Role of TRPM4 in Cardiac Disease and Arrhythmogenesis

  Maria Kontaridis
• 
  PHLPPs in cardiac physiology & pathophysiology

  Nicole Purcell
• awaiting
  The cardiac phosphatome in metabolic heart disease & failure

  Kate Weeks
• 
  PP1 isoform-specific regulation of cardiac arrhythmias

  Xander Wehrens

Metabolic reprogramming to prevent and treat heart failure

Chair

John Elrod, Issei Komuro

• 
  Understanding Human Cardiac Metabolism

  Zoltan Arany
• 
  Targeting Metabolic Maturation in the Developing and Diseased Heart

  Daniel Kelly
• 
  BCAA metabolism and HFpEF

  Tao Li
• 
  Modulating Cardiac Mitochondria with Micropeptides

  Cat Makerewich
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  Mitochondrial Transfer: a Therapy for Cardiomyopathy?

  Aijun Sun

Mitochondria, Protein homeostasis and Cell Death

Chair

Tish Murphy, Kinya Otsu

• 
  Extracellular Vesicles and Cellular Quality Control Mechanisms in Cardioprotection

  Asa Gustafsson
• 
  Role of lipid phosphate phosphatases in cardiac energy metabolism and function

  Petra Kienesberger
• awaiting
  Cross-Talk between Ferroptosis and Necroptosis

  Richard Kitsis
• 
  Mitochondrial Shape, Autophagy, and Heart Failure: a Triad to Combat.

  Luca Scorrano
• 
  Targeting the JAK1-STAT3 pathway to treat cardiac proteinopathy

  Sonia Singh

Modulators of cell-cell communication in heart failure

Chair

Pilar Alcaide, Susmita Sahoo

• 
  Macrophages as protectors of mitochondrial quality in the heart and beyond

  Jose Angel Nicolas Avila
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  Innate immune memory and organ cross-talk in heart failure

  Ichiro Manabe
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  Impact of heart-derived factors from the protected and failing heart

  Julie McMullen
• 
  Exercise-induced interorgan communication

  Kristin Stanford
• 
  Organ cross-talk during heart failure

  Thomas Thum

New mechanisms to protect against heart failure with preserved ejection fraction

Chair

David Lefer, Emiliano Medei

• awaiting
  Targeting Class IIa HDAC signaling in cardiometabolic disease

  Johannes Backs
• 
  Tyrosine kinase phosphorylation of troponin I is a novel mechanism to increase myocardial relaxation

  Brandon Biesiadecki
• 
  Unique immunometabolic treatment strategies to protect against HFpEF

  Judy de Haan
• 
  Cyclic GMP as a therapeutic target for HFpEF

  Rebecca Ritchie
• 
  Trans-differentiation of cardiac fibroblasts reveals a new molecular mechanisms for HfpEF

  Taketaro Sadahiro

New players in mitochondrial calcium regulation

Chair

Lea Delbridge, Yi Zhu

• 
  TMEM65 controls mitochondrial Ca2+ extrusion

  Diego De Stefani
• 
  Communication between LTCC and the mitochondria

  Livia Hool
• 
  Targeting mitochondrial ROS formation in cardiac pathology

  Nina Kaludercic
• 
  Sarcoplasmic reticulum-mitochondria communication in diabetic HFpEF

  Melanie Paillard
• 
  A new facet of myocardial necroptosis: crosstalk with mitochondrial dynamics and autophagy

  Toshiyuki Yano

Non-Myocyte Contributors to Arrhythmia

Chair

Bianca Brundel, Zully Pedrozo

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  Cardiac adiposity and arrhythmias

  Jim Bell
• 
  Fibroblast-Myocyte interactions and their impact on cardiac electrophysiology

  Patrizia Camelliti
• 
  Macrophages and Electrical conduction in the Heart

  Sebastian Clauss
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  Fibroblasts regulate cardiac excitability and arrhythmogenesis

  Arjun Deb
• 
  Exploring the role of neuronal dysfunction in inherited arrhythmia syndromes

  Molly O'Reilly

Regulation of endogenous cardiac regeneration

Chair

Alejandro Orlowski, Florian Weinberger

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  RNA therapies for cardiac regeneration

  Mauro Giacca
• 
  A switch in cardiac fibroblasts hinders regeneration after neonatal myocardial infarction

  Diana Nascimento
• 
  Modulating cell polarity and cytoarchitecture to promote cardiomyocyte regeneration

  Caitlin C. O'Meara
• 
  Advancing Cardiac Therapeutics

  Eldad Tzahor
• 
  Creating a repair permissive heart

  Eva van Rooij

Regulatory mechanisms of intracellular Ca2+ signalling and excitability via intracellular organelle cross-talk

Chair

Michelle Munro

• 
  Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in ARVC

  Mario Delmar
• 
  Critical role of NRSF-GNAO1 pathway in regulating Ca2+ signaling in ventricular myocytes

  Hideaki Inazumi
• 
  RyR2 as an antiarrhythmic drug target

  Bjorn C. Knollmann
• 
  Impact of Ca2+ crosstalk between mitochondria and sarcoplasmic reticulum in cardiomyocyte during workload transition

  Ayako Takeuchi
• 
  Critical role of mitochondrial remodeling in cardiac arrhythmia

  Deli Zhang

Sex matters in Cardiovascular Metabolism

Chair

Friederike Cuello, Eiki Takimoto

• 
  Genetic dissection of mitochondrial dysfunction in heart failure

  Yang Cao
• 
  Proteomic Atlas of Atherosclerosis

  Manuel Mayr
• 
  Sex differences in a newly identified heart failure syndrome

  Dhandapany Perundurai
• 
  Takotsubo Syndrome-mechanisms and Therapy

  Katrin Streckfuss-boemeke
• 
  Sex differences in diabetic-related cardiovascular disease: insights from basic science

  John Ussher

Shaping the cardiac proteome in health and disease

Chair

Lucie Carrier, Ying Ge

• 
  RNA binding proteins in stress responsive gene regulation

  Federica Accornero
• awaiting
  The unfolded protein response and ER stress

  Shirin Doroudgar
• 
  Proteostasis in hypertrophic cardiomyopathy

  Diederik Kuster
• 
  Myosin S2 and cMyBP-C Interactions in Cardiac Function and Hypertrophic Cardiomyopathy

  Sakthivel Sadayappan
• 
  Regulation of the cardiac translatome

  Yibin Wang

Spatial organization of protein synthesis in the myocardium

Chair

Tim Kamp, Llewelyn Roderick

• 
  Beta 1 and beta 2 receptor translation dynamics in healthy and failing heart

  Julia Gorelik
• 
  Localized protein translation in the heart

  Izhak Kehat
• 
  The tubulin code as spatial regulator - what can we learn from the brain?

  Marie-Jo Moutin
• 
  Microtubule-mediated spatial control: directing translation and remodeling in the myocardium

  Benjamin L. Prosser
• 
  Coordinated cotranslational association of ion channels mRNA in the heart

  Gail A. Robertson

Targeting metabolism to prevent heart failure progression: HFrEF vs HFpEF

Chair

Derek Hausenloy, Yumiko Oishi

• 
  Targeting nicotinamide adenine dinucleotide for the treatment of HFpEF

  Mahmoud Abdellatif
• 
  Targeting glucose-derived O-GlcNAcylation pathway in heart failure

  Luc Bertrand
• 
  Mitochondria in HFpEF

  Rong Tian
• 
  Myocardial proteome defines the continuum in human HFpEF

  Jenny van Eyk
• 
  The protective role of exercise on children metabolic syndrome

  Ming Xu